Assessing the nitric oxide efficacy in bilateral lung transplantation

Background . One of the most frequent and severe complications in early postoperative period lung transplantation is primary graft dysfunction resulting from ischemia-reperfusion injury. There evidence effectiveness using inhaled nitric oxide order to prevent such Objective To assess intra- bilateral transplantation. Material methods We examined 43 patients who underwent at N.V. Sklifosovsky Research Institute for Emergency Medicine 2012-2021. The were divided into two groups. study group consisted 23 patients, whose complex treatment included use oxide. Patients comparison (n=20) received a standard therapy. end points were: mechanical ventilation duration, frequency extracorporeal membrane oxygenation its mortality, dynamics index, blood lactate level, pH, base deficiency. Results therapy during improved ventilation-perfusion ratio, as evidenced by an increase index 1.1 times (p=0.128) 1.3 (p=0.026) 48 72 hours after surgery, respectively. Meanwhile, surgery was found decrease 1.2 (p=0.033), that decreased 1.4 (p=0.474); duration (p=0.042); 1.6 (p=0.028); mortality reduced 8%. Conclusion had positive effect on period, indicated improvement gas parameters, reduction veno-arterial oxygenation, ventilation.